Genome Wide Adaptations of Plasmodium falciparum in Response to Lumefantrine Selective Drug Pressure

Abstract

The combination therapy of the Artemisinin-derivative Artemether (ART) with Lumefantrine (LM) (Coartem®) is an important malaria treatment regimen in many endemic countries. Resistance to Artemisinin has already been reported, and it is feared that LM resistance (LMR) could also evolve quickly. Therefore molecular markers which can be used to track Coartem… (More)
DOI: 10.1371/journal.pone.0031623

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