Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat

@inproceedings{Atanur2013GenomeSR,
  title={Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat},
  author={Santosh S. Atanur and Ana Garcia Diaz and Klio Maratou and Allison B. Sarkis and Maxime Rotival and Laurence Game and Michael R. Tschannen and Pamela Jane Kaisaki and Georg W. Otto and Man Chun John Ma and Thomas M Keane and Oliver Hummel and Kathrin Saar and Wei Yea Chen and Victor Guryev and Kathirvel Gopalakrishnan and Michael R. Garrett and Bina Joe and Lorena Citterio and Giuseppe Bianchi and Martin W. McBride and Anna F. Dominiczak and David J. Adams and Tadao Serikawa and Paul Flicek and Edwin Cuppen and Norbert Hubner and Enrico Petretto and Dominique Gauguier and Anne E Kwitek and Howard J. Jacob and Timothy J. Aitman},
  booktitle={Cell},
  year={2013}
}
Large numbers of inbred laboratory rat strains have been developed for a range of complex disease phenotypes. To gain insights into the evolutionary pressures underlying selection for these phenotypes, we sequenced the genomes of 27 rat strains, including 11 models of hypertension, diabetes, and insulin resistance, along with their respective control strains. Altogether, we identified more than 13 million single-nucleotide variants, indels, and structural variants across these rat strains… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 56 times over the past 90 days. VIEW TWEETS