• DOI:10.1126/SCIENCE.1125134
Corpus ID: 39823899

Genome Sequence Diversity and Clues to the Evolution of Variola (Smallpox) Virus

@article{Esposito2006GenomeSD,
  title={Genome Sequence Diversity and Clues to the Evolution of Variola (Smallpox) Virus},
  author={J. Esposito and S. Sammons and A. Frace and John D Osborne and Melissa A. Olsen-Rasmussen and M. Zhang and Dhwani Govil and I. Damon and R. Kline and M. Laker and Yu Li and G. Smith and H. Meyer and J. Leduc and Robert M. Wohlhueter},
  journal={Science},
  year={2006},
  volume={313},
  pages={807 - 812}
}

• J. Esposito, S. Sammons, +12 authors Robert M. Wohlhueter
• Published 2006
• Biology, Medicine
• Science

Comparative genomics of 45 epidemiologically varied variola virus isolates from the past 30 years of the smallpox era indicate low sequence diversity, suggesting that there is probably little difference in the isolates' functional gene content. Phylogenetic clustering inferred three clades coincident with their geographical origin and case-fatality rate; the latter implicated putative proteins that mediate viral virulence differences. Analysis of the viral linear DNA genome suggests that its… Expand

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