Genome Scale Patterns of Recombination between Coinfecting Vaccinia Viruses

  title={Genome Scale Patterns of Recombination between Coinfecting Vaccinia Viruses},
  author={Li Qin and David H. Evans},
  journal={Journal of Virology},
  pages={5277 - 5286}
ABSTRACT Recombination plays a critical role in virus evolution. It helps avoid genetic decline and creates novel phenotypes. This promotes survival, and genome sequencing suggests that recombination has facilitated the evolution of human pathogens, including orthopoxviruses such as variola virus. Recombination can also be used to map genes, but although recombinant poxviruses are easily produced in culture, classical attempts to map the vaccinia virus (VACV) genome this way met with little… 
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