Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

  title={Genome Regulation by Polycomb and Trithorax: 70 Years and Counting},
  author={Bernd Schuettengruber and Henri-Marc Bourbon and Luciano Di Croce and Giacomo Cavalli},
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic cellular memory system that maintains repressed or active gene expression states. Recently, they have been shown to globally control a plethora of cellular processes. This functional diversity is achieved by their ability to regulate chromatin at multiple levels, ranging from modifying local chromatin structure to orchestrating the three… CONTINUE READING
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