Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development.

@article{Smith2016GenomeEO,
  title={Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development.},
  author={Brenden William Smith and E A Feigenbaum Stanford and David H. Sherr and George J Murphy},
  journal={Stem cells international},
  year={2016},
  volume={2016},
  pages={
          2574152
        }
}
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that increases the expression of detoxifying enzymes upon ligand stimulation. Recent studies now suggest that novel endogenous roles of the AHR exist throughout development. In an effort to create an optimized model system for the study of AHR signaling in several cellular lineages, we have employed a CRISPR/CAS9 genome editing strategy in induced pluripotent stem cells (iPSCs) to incorporate a reporter cassette at… CONTINUE READING

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