Genome Context as a Predictive Tool for Identifying Regulatory Targets of the TetR Family Transcriptional Regulators

@inproceedings{Ahn2012GenomeCA,
  title={Genome Context as a Predictive Tool for Identifying Regulatory Targets of the TetR Family Transcriptional Regulators},
  author={Sang Kyun Ahn and Leslie Cuthbertson and Justin R Nodwell},
  booktitle={PloS one},
  year={2012}
}
TetR family transcriptional regulators (TFRs) are found in most bacteria and archea. Most of the family members that have been investigated to date are repressors of their target genes, and the majority of these, like the well-characterized protein TetR, regulate genes that encode transmembrane efflux pumps. In many cases repression by TFR proteins is reversed through the direct binding of a small-molecule ligand. The number of TFRs in the public database has grown rapidly as a result of genome… CONTINUE READING

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