Genome-Based Discovery of a Novel Membrane-Bound 1,6-Dihydroxyphenazine Prenyltransferase from a Marine Actinomycete

@inproceedings{Zeyhle2014GenomeBasedDO,
  title={Genome-Based Discovery of a Novel Membrane-Bound 1,6-Dihydroxyphenazine Prenyltransferase from a Marine Actinomycete},
  author={Philipp Zeyhle and Judith S. Bauer and J{\"o}rn Kalinowski and Kazuo Shin-Ya and Harald Gross and Lutz Heide},
  booktitle={PloS one},
  year={2014}
}
Recently, novel prenylated derivatives of 1,6-dihydroxyphenazine have been isolated from the marine sponge-associated Streptomyces sp. SpC080624SC-11. Genome sequencing of this strain now revealed a gene cluster containing all genes necessary for the synthesis of the phenazine and the isoprenoid moieties. Unexpectedly, however, the cluster did not contain a gene with similarity to previously investigated phenazine prenyltransferases, but instead a gene with modest similarity to the membrane… CONTINUE READING