Genome Analysis Reveals Interplay between 5′UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes

@article{Cenik2011GenomeAR,
  title={Genome Analysis Reveals Interplay between 5′UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes},
  author={Can Cenik and H. Chua and Hui Zhang and Stefan P Tarnawsky and Abdalla Akef and A. Derti and M. Tasan and M. Moore and Alexander F Palazzo and F. P. Roth},
  journal={PLoS Genetics},
  year={2011},
  volume={7}
}
In higher eukaryotes, messenger RNAs (mRNAs) are exported from the nucleus to the cytoplasm via factors deposited near the 5′ end of the transcript during splicing. The signal sequence coding region (SSCR) can support an alternative mRNA export (ALREX) pathway that does not require splicing. However, most SSCR–containing genes also have introns, so the interplay between these export mechanisms remains unclear. Here we support a model in which the furthest upstream element in a given transcript… Expand
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TLDR
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