Genome‐wide identification of pseudogenes capable of disease‐causing gene conversion

@article{Bischof2006GenomewideIO,
  title={Genome‐wide identification of pseudogenes capable of disease‐causing gene conversion},
  author={Jared Bischof and Annie P. Chiang and Todd E. Scheetz and Edwin M. Stone and Thomas L. Casavant and Val C. Sheffield and Terry A. Braun},
  journal={Human Mutation},
  year={2006},
  volume={27}
}
Pseudogenes are remnants of gene duplication (nonprocessed pseudogenes) and retrotransposition (processed pseudogenes) events. This study describes methods for identifying gene conversion candidates from predicted pseudogenes. Pseudogenes may accumulate and harbor sequence variations over time that become disease‐causing mutations when transferred to genes by gene conversion. A total of 14,476 pseudogenes were identified, including 3,426 nonprocessed pseudogenes. In addition, 1,945 nonprocessed… 
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