Genome‐Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians

@article{Yau2017GenomeWideAS,
  title={Genome‐Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians},
  author={M. Yau and L. Yerges-Armstrong and Youfang Liu and C. Lewis and D. Duggan and J. Renner and J. Torner and D. Felson and C. McCulloch and C. Kwoh and M. Nevitt and M. Hochberg and B. Mitchell and J. Jordan and R. Jackson},
  journal={Arthritis \& Rheumatology},
  year={2017},
  volume={69}
}
A major barrier to genetic studies of osteoarthritis (OA) is the need to obtain large numbers of individuals with standardized radiographic evaluations for OA. To address this gap, we performed a genome‐wide association study (GWAS) of radiographically defined tibiofemoral knee OA in 3,898 cases and 3,168 controls from 4 well‐characterized North American cohorts, and we performed replication analysis of previously reported OA loci. 
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