Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

  title={Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis},
  author={Sergio E Baranzini and Joann Mudge and Jennifer C. van Velkinburgh and Pouya Khankhanian and Irina Khrebtukova and Neil A Miller and Lu Zhang and Andrew D. Farmer and Callum J. Bell and Ryan W. Kim and Gregory D. May and Jimmy E. Woodward and Stacy J. Caillier and Joseph P. McElroy and Refujia Gomez and Marcelo Jorge Pando and Leonda E. Clendenen and Elena E. Ganusova and Faye D. Schilkey and Thiru Ramaraj and Omar A. Khan and Jim J. Huntley and Shujun Luo and Pui-Yan Kwok and Thomas D. Wu and Gary P. Schroth and Jorge Oksenberg and Stephen L. Hauser and Stephen F Kingsmore},
Monozygotic or ‘identical’ twins have been widely studied to dissect the relative contributions of genetics and environment in human diseases. In multiple sclerosis (MS), an autoimmune demyelinating disease and common cause of neurodegeneration and disability in young adults, disease discordance in monozygotic twins has been interpreted to indicate environmental importance in its pathogenesis. However, genetic and epigenetic differences between monozygotic twins have been described, challenging… CONTINUE READING
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