Genital herpes

  title={Genital herpes},
  author={Rachna Gupta and Terri J Warren and Anna Wald},
  journal={The Lancet},

Herpes simplex virus type 2 inhibits TNF-α-induced NF-κB activation through viral protein ICP22-mediated interaction with p65

Herpes simplex virus type 2 (HSV-2) is a prevalent human pathogen and the main cause of genital herpes. After initial infection, HSV-2 can establish lifelong latency within dorsal root ganglia by

The association between Herpes simplex virus type 2 and asthma: A cross-sectional study from National Health and Nutrition Examination Survey 1999–2016

There was a positive association between HSV-2 infection and asthma, and participants who were male, White race, 30 years ≤ age < 40 years, BMI ≥ 28 kg/m2, 1.39 ≤ ratio of family income to poverty (PIR) < 3.49 and smokers should receive more attention.

Pharmacokinetics and Safety Study of HN0037, a Novel Anti-Human Herpes Simplex Virus Inhibitor, in Healthy Volunteers.

  • J. HouH. Gao G. Hill
  • Medicine, Biology
    Clinical pharmacology in drug development
  • 2022
The results demonstrate that HN0037 is safe and well-tolerated, supporting further clinical development and indicated that a high-fat meal had a marginal impact on HN00037's pharmacokinetics.

Promising Role of Emodin as Therapeutics to Against Viral Infections

This review aims to summarize the antiviral effect of emodin, in order to provide reference and hopes to support the further investigations.

JieZe-1 Alleviates HSV-2 Infection-Induced Genital Herpes in Balb/c Mice by Inhibiting Cell Apoptosis via Inducing Autophagy

JZ-1 can alleviate HSV-2 infection-induced GH in balb/c mice by inhibiting cell apoptosis via inducing autophagy, and the underlying mechanisms may be associated with the inhibition of PI3K/Akt/mTOR pathway.

Pathogenesis and virulence of herpes simplex virus

The HSV life cycle, the interaction of HSV with the immune system and three of the best-studied pathologies are reviewed, including Herpes stromal keratitis, herpes simplex encephalitis and genital herpes.

Potential of mucoadhesive chitosan glutamate microparticles as microbicide carriers – antiherpes activity and penetration behavior across the human vaginal epithelium

Ex vivo penetration studies revealed that gCS increased the accumulation of active agent in the vaginal epithelium but surprisingly did not facilitate its penetration across human tissue, and obtained antiviral results demonstrated the potential of gCS as an antiherpes adjunctive, whose mode of action was related to blocking viral attachment.