Genistein suppresses tumor necrosis factor-alpha-induced proliferation via the apoptotic signaling pathway in human aortic smooth muscle cells.

@article{Kim2010GenisteinST,
  title={Genistein suppresses tumor necrosis factor-alpha-induced proliferation via the apoptotic signaling pathway in human aortic smooth muscle cells.},
  author={Hyuck Kim and M J Lee and Jai-Eun Kim and Sun-Dong Park and Hyung-in Moon and Won-Hwan Park},
  journal={Journal of agricultural and food chemistry},
  year={2010},
  volume={58 3},
  pages={2015-9}
}
The proliferation of vascular smooth muscle cells (VSMCs) plays a key role in the development of atherosclerosis. Abnormal VSMC proliferation induces vascular dysfunction and several other pathological processes. The present study investigated the apoptotic effects of genistein on tumor necrosis factor-alpha (TNF-alpha)-induced proliferation in human aortic smooth muscle cells (HASMCs). The apoptotic effects of genistein were assessed to determine the mechanism(s) of its antiproliferative… CONTINUE READING