Genistein sensitizes TRAIL-resistant human gastric adenocarcinoma AGS cells through activation of caspase-3.

Abstract

The cytotoxic effect of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is limited in some cancer cells, including AGS gastric adenocarcinoma cells. However, treatment with TRAIL in combination with subtoxic concentrations of genistein sensitizes TRAIL-resistant AGS cells to TRAIL-mediated apoptosis. Combined treatment with genistein and… (More)

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Cite this paper

@article{Jin2007GenisteinST, title={Genistein sensitizes TRAIL-resistant human gastric adenocarcinoma AGS cells through activation of caspase-3.}, author={C. Bum-Seung Jin and Cheol Park and Jaehun Cheong and Byung Tae Choi and Tae-Ho Lee and Jae-Dong Lee and Won ho Lee and Gi-young Kim and Chung Ho Ryu and Young Hyun Choi}, journal={Cancer letters}, year={2007}, volume={257 1}, pages={56-64} }