Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation.

@article{Wang2010GenisteinPA,
  title={Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation.},
  author={Yi Na Wang and Wei Chen Wu and Hong Chao Chen and Hong Fang},
  journal={Journal of dermatological science},
  year={2010},
  volume={58 1},
  pages={
          19-27
        }
}
  • Yi Na Wang, Wei Chen Wu, +1 author Hong Fang
  • Published in
    Journal of dermatological…
    2010
  • Biology, Medicine
  • BACKGROUND Genistein, as an active compound of dietary antioxidants, has shown considerable promise as an effective agent against aging process. However, the effect of genistein on skin photoaging and the associated mechanism remain unclear. OBJECTIVE To delineate the effect of genistein on UVB-induced senescence in human dermal fibroblasts (HDFs) with emphasis on the mechanism of oxidative pathway regulated by p66Shc involved in the events. METHODS HDFs were induced to premature senescence… CONTINUE READING

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