Genistein potentiates wild-type and delta F508-CFTR channel activity.

  title={Genistein potentiates wild-type and delta F508-CFTR channel activity.},
  author={Tzyh-Chang Hwang and Fengzhen Wang and Iris C-H Yang and William W. Reenstra},
  journal={The American journal of physiology},
  volume={273 3 Pt 1},
Effects of genistein on wild-type (wt) and delta F508-cystic fibrosis transmembrane conductance regulator (CFTR) were studied in NIH/3T3 cells stably transfected with wt or mutant CFTR cDNA. As measured by I- efflux, half-maximal concentration of agonist (K1/2) for forskolin-dependent activation was greater for delta F508-CFTR than wt-CFTR. Genistein decreased the K1/2 for both forms of the channel and increased the maximal activity of delta F508-CFTR by 3.7-fold. In cell-attached patches, 10… CONTINUE READING
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