Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells

@inproceedings{Guo2013GenisteinIW,
  title={Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells},
  author={Jia Guo and Xuehua Xu and Taban K Rasheed and Alyson C Yoder and Dongyang Yu and Huizhi Liang and Fei Yi and Todd S. Hawley and Tian Jin and Binhua Ling and Yuntao Wu},
  booktitle={Retrovirology},
  year={2013}
}
Binding of HIV to the chemokine coreceptor CXCR4 mediates viral fusion and signal transduction that promotes actin dynamics critical for HIV infection of blood resting CD4 T cells. It has been suggested that this gp120-mediated actin activity resembles the chemotactic actin dynamics mediated by chemokines such as SDF-1. To determine whether inhibiting SDF-1-mediated chemotactic activity can also inhibit HIV infection, we screened several inhibitors known to reduce SDF-1-mediated chemotaxis of T… CONTINUE READING
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