Genistein inhibits the proliferation of human HER 2-positive cancer cells by downregulating HER 2 receptor

@inproceedings{Shen2013GenisteinIT,
  title={Genistein inhibits the proliferation of human HER 2-positive cancer cells by downregulating HER 2 receptor},
  author={Guodong Shen and Haiying Yu and Geng Bian and Min Gao and Lingqing Liu and Min Cheng and Gan Shen and Shilian Hu},
  year={2013}
}
Background: It was well studied that HER2/ErbB2/p185 overexpression in human malignant cancers correlates with poor prognosis and chemo-resistance. Meanwhile, Genistein (4,5,7trihydroxyisoflavone), a major isoflavone component of soybeans and other leguminous plants, has been shown to exhibit a potent anti-proliferative effect on some sex hormone dependent cancers. Objective: The effects of genistein on the proliferation of human HER2-overexpressing breast and ovarian cancer cell lines were… CONTINUE READING
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