Genistein inhibits the contact-stimulated migration of prostate cancer cells

  title={Genistein inhibits the contact-stimulated migration of prostate cancer cells},
  author={Katarzyna Miekus and Zbigniew Madeja},
  journal={Cellular \& Molecular Biology Letters},
The results of several epidemiological studies have suggested that a soybean-based diet is associated with a lower risk of prostate cancer. We investigated the effect of the soy isoflavone genistein on the proliferation and contact-stimulated migration of rat prostatic carcinoma MAT-LyLu and AT-2 cell lines. Genistein almost completely inhibited the growth of both MAT-LyLu and AT-2 cells in the concentration range from 25 to 100 μM, but the addition of 1 μM genistein to the medium significantly… 

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  • Biology, Chemistry
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2001
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