Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells.

@article{Jones2002GenisteinIT,
  title={Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells.},
  author={Julie L Jones and Brian J. Daley and Blaine L. Enderson and Jingxiong Zhou and Michael Donald Karlstad},
  journal={The American surgeon},
  year={2002},
  volume={68 6},
  pages={
          575-7; discussion 577-8
        }
}
Tamoxifen is an antiestrogen used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. It functions by competitively inhibiting the estrogen receptor and inducing apoptosis and G1 cell cycle arrest. Genistein is a soy phytoestrogen that inhibits breast cancer cell growth in vitro at doses of 10 microM or above. At lower doses genistein may stimulate cell growth and entry into the cell cycle. We hypothesized that treatment with low-dose genistein would reverse… CONTINUE READING
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