Genistein inhibits proliferation and functions of hypertrophic scar fibroblasts.


Hypertrophic scarring is abnormal proliferation of dermal fibroblasts and excessive deposition of extracellular matrix. To date, despite many studies, treatments have not been satisfactory. Genistein, a potent, specific inhibitor of tyrosine protein kinases (TPKs), has been proved to inhibit many kinds of tumour and some fibrotic diseases. The purpose of… (More)
DOI: 10.1016/j.burns.2008.03.011

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