Genistein inhibits nonoxidative ribose synthesis in MIA pancreatic adenocarcinoma cells: a new mechanism of controlling tumor growth.

@article{Boros2001GenisteinIN,
  title={Genistein inhibits nonoxidative ribose synthesis in MIA pancreatic adenocarcinoma cells: a new mechanism of controlling tumor growth.},
  author={L{\'a}szl{\'o} G. Boros and Sara Bassilian and Shu Hui Lim and Wai Nang Paul Lee},
  journal={Pancreas},
  year={2001},
  volume={22 1},
  pages={1-7}
}
Genistein is a plant isoflavonoid bearing potent tumor growth-regulating characteristics. This effect of genistein has been attributed partially to its tyrosine kinase-regulating properties, resulting in cell-cycle arrest and limited angiogenesis. Genistein has been used in chemotherapy-resistant cases of advanced leukemia with promising results. Here we demonstrate that genistein primarily affects nucleic acid synthesis and glucose oxidation in tumor cells using the [1,2-(13)C2]glucose isotope… CONTINUE READING
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