Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis.

@article{Gu2005GenisteinII,
  title={Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis.},
  author={Yan Yun Gu and Chen-Fang Zhu and Hitoshi Iwamoto and Ji-sheng Chen},
  journal={World journal of gastroenterology},
  year={2005},
  volume={11 41},
  pages={
          6512-7
        }
}
AIM To study the in vitro and in vivo inhibitory effects of genistein on invasive potential of Bel 7402 hepatocellular carcinoma (HCC) cells and to explore the underlying mechanism. METHODS Bel 7402 HCC cells were exposed to genistein. The invasive activity of tumor cells was assayed in transwell cell culture chamber. p125FAK expression and cell cycle were evaluated by a functional assay. Cell apoptosis analysis was performed with TUNEL method. In addition, bilateral subrenal capsule… CONTINUE READING

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