Genistein inhibits cardiac L-type Ca(2+) channel activity by a tyrosine kinase-independent mechanism.

@article{Belevych2002GenisteinIC,
  title={Genistein inhibits cardiac L-type Ca(2+) channel activity by a tyrosine kinase-independent mechanism.},
  author={Andriy E Belevych and Sunita Warrier and Robert D. Harvey},
  journal={Molecular pharmacology},
  year={2002},
  volume={62 3},
  pages={554-65}
}
It has been suggested that protein tyrosine kinase (PTK) activity can directly regulate cardiac L-type Ca(2+) channels. This conclusion is based to a large extent on the observation that the PTK inhibitor genistein can inhibit the cardiac L-type Ca(2+) current. The purpose of the present study was to determine whether the ability of genistein to inhibit cardiac L-type Ca(2+) channel activity is due to inhibition of PTK activity. Genistein significantly reduced the magnitude of the L-type Ca(2… CONTINUE READING
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