Genistein inhibits aldose reductase activity and high glucose-induced TGF-beta2 expression in human lens epithelial cells.

@article{Kim2008GenisteinIA,
  title={Genistein inhibits aldose reductase activity and high glucose-induced TGF-beta2 expression in human lens epithelial cells.},
  author={Young Han Kim and Nan Hee Kim and Dong Ho Jung and Dae Sik Jang and Yun mi Lee and Jong Min Kim and Junghyun Kim},
  journal={European journal of pharmacology},
  year={2008},
  volume={594 1-3},
  pages={
          18-25
        }
}
Aldose reductase (AR) and TGF-beta have been implicated in the development of diabetic complications, such as cataracts. In an attempt to obtain potential agents for the prevention of diabetic cataracts from natural products, we purified genistein from the roots of Pueraria lobata and investigated its inhibitory effects upon AR activity and its antioxidant effects on rat lenses. The inhibition of AR activity by genistein increased in a dose-dependent manner and the opacities of lenses were… CONTINUE READING
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