Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification.

@article{Majid2008GenisteinIT,
  title={Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification.},
  author={Shahana Majid and Nobuyuki Kikuno and Jason L Nelles and Emily J. Noonan and Yuichiro Tanaka and Ken Kawamoto and Hiroshi Hirata and Long Li and Haishuang Zhao and Steve T Okino and Robert F. Place and Deepa Pookot and Rajvir Dahiya},
  journal={Cancer research},
  year={2008},
  volume={68 8},
  pages={2736-44}
}
Genistein (4',5,7-trihydroxyisoflavone) is the most abundant isoflavone found in the soybean. The effects of genistein on various cancer cell lines have been extensively studied but the precise molecular mechanisms are not known. We report here the epigenetic mechanism of the action of genistein on androgen-sensitive (LNCaP) and androgen-insensitive (DuPro) human prostate cancer cell lines. Genistein induced the expression of tumor suppressor genes p21 (WAF1/CIP1/KIP1) and p16 (INK4a) with a… CONTINUE READING

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