Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells.

@article{Salti2000GenisteinIA,
  title={Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells.},
  author={George I. Salti and Suman Grewal and Rajeshwari R. Mehta and Tapas K. Das Gupta and Arthur W. Boddie and Andreas I. Constantinou},
  journal={European journal of cancer},
  year={2000},
  volume={36 6},
  pages={796-802}
}
The present study was undertaken to determine if (a) genistein induces topo II-mediated DNA damage in HT-29 colon cancer cells; and (b) if this damage is required to induce apoptosis. DNA damage was evaluated using the comet assay. Apoptosis was determined by the ethidium bromide/acridine orange staining technique. DNA breakage was noted within 1 h of treatment. Apoptosis was only induced with high concentrations (>/=60 microM) of genistein. Marked inhibition of HT-29 cell growth was evident at… CONTINUE READING

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