Genistein increases gene expression by demethylation of WNT5a promoter in colon cancer cell line SW1116.

@article{Wang2010GenisteinIG,
  title={Genistein increases gene expression by demethylation of WNT5a promoter in colon cancer cell line SW1116.},
  author={Zuguang Wang and Hong Chen},
  journal={Anticancer research},
  year={2010},
  volume={30 11},
  pages={4537-45}
}
Genistein (GEN), one of the soy isoflavones, exhibits protection against colon cancer. The WNT signaling pathway plays a critical role in both normal epithelial regeneration and tumorigenesis in human colon. In this study it was hypothesized that GEN regulates specific genes in the WNT signaling pathway. Colon cancer cell lines DLD-1, SW480, and SW1116 were treated with Novasoy or GEN for 4 days. mRNA levels of several WNT signaling components were analyzed by real-time PCR. Methylation… CONTINUE READING
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