Genistein enhances the NGF-induced neurite outgrowth.

  title={Genistein enhances the NGF-induced neurite outgrowth.},
  author={Ken-ichi Nakajima and Naomi Niisato and Yoshinori Marunaka},
  journal={Biomedical research},
  volume={32 5},
In the present report, we studied if an isoflavone, genistein, enhances the nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells. Application of genistein enhanced the NGF-induced neurite outgrowth. Knockdown of Na+/K+/2Cl- cotransporter isoform 1 (NKCC1) abolished the stimulatory effect of genistein on the neurite outgrowth. These observations indicate that NKCC1 is essential for genistein to stimulate the NGF-induced neurite outgrowth, although genistein had no effect on the… CONTINUE READING