Genistein attenuates ischemic oxidative damage and behavioral deficits via eNOS/Nrf2/HO-1 signaling.

@article{Wang2013GenisteinAI,
  title={Genistein attenuates ischemic oxidative damage and behavioral deficits via eNOS/Nrf2/HO-1 signaling.},
  author={Ruimin Wang and Jingyi Tu and Quanguang Zhang and Xiaoying Zhang and Ying Zhu and Wendong Ma and Cheng Cheng and Darrell W Brann and Fang Yang},
  journal={Hippocampus},
  year={2013},
  volume={23 7},
  pages={634-47}
}
Global cerebral ischemia, such as occurs following cardiac arrest, can lead to oxidative stress, hippocampal neuronal cell death, and cognitive defects. The current study examined the potential beneficial effect and underlying mechanisms of post-treatment with the naturally occurring isoflavonic phytoestrogen, genistein, which has been implicated to attenuate oxidative stress. Genistein (1 mg kg(-1)) was administered i.v. 5 min after reperfusion in rats subjected to four-vessel global cerebral… CONTINUE READING

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