Genistein attenuates hypoxic pulmonary hypertension via enhanced nitric oxide signaling and the erythropoietin system.

@article{Kuriyama2014GenisteinAH,
  title={Genistein attenuates hypoxic pulmonary hypertension via enhanced nitric oxide signaling and the erythropoietin system.},
  author={Sachiko Kuriyama and Yoshiteru Morio and Michie Toba and Tetsutaro Nagaoka and Fumiyuki Takahashi and Shin-ichiro Iwakami and Kuniaki Seyama and Kazuhisa Takahashi},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2014},
  volume={306 11},
  pages={L996-L1005}
}
Upregulation of the erythropoietin (EPO)/EPO receptor (EPOR) system plays a protective role against chronic hypoxia-induced pulmonary hypertension (hypoxic PH) through enhancement of endothelial nitric oxide (NO)-mediated signaling. Genistein (Gen), a phytoestrogen, is considered to ameliorate NO-mediated signaling. We hypothesized that Gen attenuates and prevents hypoxic PH. In vivo, Sprague-Dawley rats raised in a hypobaric chamber were treated with Gen (60 mkg/kg) for 21 days. Pulmonary… CONTINUE READING