Genistein and zinc synergistically stimulate apoptotic cell death and suppress RANKL signaling-related gene expression in osteoclastic cells.

Abstract

The effects of the combination of genistein and zinc, which have an anabolic effect on bone metabolism, on osteoclastic cells in mouse marrow culture system in vitro was investigated. The macrophage colony-stimulating factor (M-CSF)-dependent bone marrow macrophages were cultured in the presence of M-CSF (10 ng/ml) and receptor activator of nuclear factor… (More)

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@article{Uchiyama2007GenisteinAZ, title={Genistein and zinc synergistically stimulate apoptotic cell death and suppress RANKL signaling-related gene expression in osteoclastic cells.}, author={Satoshi Uchiyama and Masayoshi Yamaguchi}, journal={Journal of cellular biochemistry}, year={2007}, volume={101 3}, pages={529-42} }