Genistein and tyrphostin 47 stimulate CFTR-mediated Cl- secretion in T84 cell monolayers.

@article{Sears1995GenisteinAT,
  title={Genistein and tyrphostin 47 stimulate CFTR-mediated Cl- secretion in T84 cell monolayers.},
  author={Cynthia L Sears and F Firoozmand and Annika Mellander and Fort Chambers and I G Eromar and Alice G M Bot and Bob J Scholte and Hugo R. de Jonge and Mark Donowitz},
  journal={The American journal of physiology},
  year={1995},
  volume={269 6 Pt 1},
  pages={G874-82}
}
The involvement of tyrosine phosphorylation in the regulation of epithelial cell Cl- secretion is unknown. Therefore, the purpose of these studies was to determine if tyrosine kinase activation was involved in the regulation of Cl- secretion, using the tyrosine kinase inhibitors, genistein and tyrphostin 47, and human intestinal epithelial cells (T84 cells) as an intestinal Cl- secretory model. Genistein rapidly but reversibly stimulated sustained apical Cl- secretion in monolayers of T84 cells… CONTINUE READING

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