Genistein aglycone does not affect thyroid function: results from a three-year, randomized, double-blind, placebo-controlled trial.

@article{Bitto2010GenisteinAD,
  title={Genistein aglycone does not affect thyroid function: results from a three-year, randomized, double-blind, placebo-controlled trial.},
  author={Alessandra Bitto and Francesca Polito and Marco Atteritano and Domenica Altavilla and Susanna Mazzaferro and Herbert Marini and Elena Bianca Adamo and Rosario D'Anna and Roberta Granese and Francesco Corrado and Silvia Russo and Letteria Minutoli and Francesco Squadrito},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 6},
  pages={3067-72}
}
CONTEXT AND OBJECTIVE Genistein aglycone positively affects postmenopausal symptoms. However, questions about its long-term safety on the thyroid gland still remain. DESIGN The parent study was a randomized, double-blind, placebo-controlled trial involving 389 osteopenic, postmenopausal women for 24 months. A subcohort (138 patients) continued therapy for an additional year. SETTING Patients received ambulatory care. PATIENTS AND INTERVENTIONS Participants received 54 mg of genistein… CONTINUE READING

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