Genistein Suppresses Prostate Cancer Growth through Inhibition of Oncogenic MicroRNA-151

  title={Genistein Suppresses Prostate Cancer Growth through Inhibition of Oncogenic MicroRNA-151},
  author={Takeshi Chiyomaru and Soichiro Yamamura and Mohd Saif Zaman and Shahana Majid and Guoren Deng and Varahram Shahryari and Sharanjot Saini and Hiroshi Hirata and Koji Ueno and Inik Chang and Yuichiro Tanaka and Z. Laura Tabatabai and Hideki Enokida and Masayuki Nakagawa and Rajvir Dahiya},
  booktitle={PloS one},
Genistein has been shown to suppress the growth of several cancers through modulation of various pathways. However, the effects of genistein on the regulation of oncogenic microRNA-151 (miR-151) have not been reported. In this study, we investigated whether genistein could alter the expression of oncogenic miR-151 and its target genes that are involved in the progression and metastasis of prostate cancer (PCa). Real-time RT-PCR showed that the expression of miR-151 was higher in PC3 and DU145… CONTINUE READING
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