Genistein Inhibits Cell Growth by Modulating Various Mitogen‐Activated Protein Kinases and AKT in Cervical Cancer Cells
@article{Kim2009GenisteinIC, title={Genistein Inhibits Cell Growth by Modulating Various Mitogen‐Activated Protein Kinases and AKT in Cervical Cancer Cells}, author={Su-Hyeon Kim and Su-Hyeong Kim and Yong‐Beom Kim and Yong Tark Jeon and Sang-C. Lee and Yong Sang Song}, journal={Annals of the New York Academy of Sciences}, year={2009}, volume={1171} }
Genistein, a soy‐derived isoflavone, inhibits growth of tumor cells from various malignancies. Here we investigated the effect of genistein on the growth of cervical cancer cells (HeLa and CaSki) and its possible mechanism. Genistein significantly suppressed cell growth of HeLa and CaSki cells at concentrations of 20 and 60 μmol/L, respectively, for 24 h. Western blotting analysis showed that genistein reduced phosphorylation of AKT and extracellular signal–regulated kinase (ERK)‐1/2 and…
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