Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: involvement of estrogen receptors, ERK1/2, and NFkappaB.

@article{Borrs2006GenisteinAS,
  title={Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: involvement of estrogen receptors, ERK1/2, and NFkappaB.},
  author={Consuelo Borr{\'a}s and Juan Pablo Gambini and Mari-Carmen G{\'o}mez-Cabrera and Juan Sastre and Federico Vicente Pallard{\'o} and Giovanni E. Mann and J. Vi{\~n}a},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 12},
  pages={2136-8}
}
We have previously reported that estrogens up-regulate longevity-associated genes. As recent evidence has shown that estrogen replacement therapy is associated with an increased risk of cardiovascular disease, we have studied the effects of genistein, a soy isoflavone with a similar structure to estradiol, on the expression of antioxidant, longevity-related genes. MCF-7 cells (human mammary gland tumor cell line) were incubated for 48 h with 0.5 microM genistein, a concentration found in the… CONTINUE READING

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