Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells.

@article{Guo2017GeniposideII,
  title={Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells.},
  author={Lixia Guo and Jianhui Liu and Xu-xu Zheng and Zhong-yi Yin and Jayasankar Kosaraju and Kin Y. Tam},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2017},
  volume={110},
  pages={
          70-76
        }
}
Our previous work revealed that in the pancreatic β cell line, geniposide modulated ATP production and glucose-stimulated insulin secretion (GSIS) induced by the acute stimulation of high glucose concentration. However, the effects of geniposide on functional impairment and the mass of β-cells exposed to elevated levels of glucose remains unknown. In the present study, impaired GSIS and restrained proliferation were observed in the prolonged culture of insulinoma INS-1 cells with 33mM of… CONTINUE READING

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