Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway.

@article{Jiang2016GeniposidePH,
  title={Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway.},
  author={You-qin Jiang and Guang-Lei Chang and Ying Wang and Dong-ying Zhang and Li Cao and Jian Liu},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2016},
  volume={39 1},
  pages={407-21}
}
BACKGROUND/AIMS Myocardial ischemia/reperfusion injury is a major cause of morbidity and mortality associated with coronary heart disease. Many studies have demonstrated that natural products are promising chemotherapeutic drugs counteracting the loss of cardiomyocytes. Thus, the purpose of the present study was to investigate the effects of geniposide, a traditional Chinese herb extract from Gardenia jasminoides J. Ellis, on cardiomyocyte apoptosis induced by hypoxia/reoxygenation (H/R) in… CONTINUE READING

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Cell viability and apoptosis ratio were assessed using the cell counting kit-8 assay and Annexin V / propidium iodide ( PI ) staining .
Cell viability and apoptosis ratio were assessed using the cell counting kit-8 assay and Annexin V / propidium iodide ( PI ) staining .
The expressions of Bcl-2 mRNA and Caspase-3 mRNA were measured by reverse transcription - polymerase chain reaction ( RT - PCR ) .
The expressions of Bcl-2 mRNA and Caspase-3 mRNA were measured by reverse transcription - polymerase chain reaction ( RT - PCR ) .
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