Genipin inhibits MMP-1 and MMP-3 release from TNF-a-stimulated human periodontal ligament cells.

@article{Shindo2014GenipinIM,
  title={Genipin inhibits MMP-1 and MMP-3 release from TNF-a-stimulated human periodontal ligament cells.},
  author={Satoru Shindo and Yoshitaka Hosokawa and Ikuko Hosokawa and Kazumi Ozaki and Takashi Matsuo},
  journal={Biochimie},
  year={2014},
  volume={107 Pt B},
  pages={
          391-5
        }
}
Genipin, the aglycon of geniposide found in gardenia fruit has long been considered for treatment of inflammatory diseases in traditional oriental medicine. Genipin has recently been reported to have some pharmacological functions, such as antimicrobial, antitumor, and anti-inflammatory effects. The aim of this study was to examine whether genipin could modify matrix metalloproteinase (MMP)-1 and MMP-3, which are related to the destruction of periodontal tissues in periodontal lesion… CONTINUE READING

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