Genipin attenuates sepsis by inhibiting Toll-like receptor signaling.

@article{Kim2012GenipinAS,
  title={Genipin attenuates sepsis by inhibiting Toll-like receptor signaling.},
  author={Tae-Hoon Kim and Seong-Jin Yoon and Sun-Mee Lee},
  journal={Molecular medicine},
  year={2012},
  volume={18},
  pages={
          455-65
        }
}
The pathogenesis of sepsis is characterized by overwhelming inflammatory responses that lead to tissue damage and organ failure. Toll-like receptor (TLR) signaling is crucial for induction of hyperinflammatory responses and tissue injury during sepsis. Genipin, an aglycon of geniposide, has antiinflammatory and antimicrobial activities. The purpose of this study was to test the hypothesis that genipin reduces multiple organ dysfunction and mortality during sepsis through inhibition of TLR… CONTINUE READING
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