Geninthiocins C and D from Streptomyces as 35-membered macrocyclic thiopeptides with modified tail moiety

  title={Geninthiocins C and D from Streptomyces as 35-membered macrocyclic thiopeptides with modified tail moiety},
  author={Shufen Li and Xin-xin Hu and Linli Li and Hongyu Liu and Liyan Yu and Xuefu You and Bingya Jiang and Linzhuan Wu},
  journal={The Journal of Antibiotics},
Geninthiocin is a thiopeptide with 35-membered macrocyclic core moiety. It has potent anti-Gram-positive (G+) bacteria activity. Herein, we reported two new congeners (2-3) of geninthiocin (geninthiocin A, 1) from Streptomyces sp. CPCC 200267, and designated them as geninthiocins C and D, whose structures were determined by NMR. Geninthiocins A, C and D had the same 35-membered macrocyclic core moiety, but possessed a -Dha-Dha-NH2, -Dha-Ala-NH2, and -NH2 tail, respectively. Besides, the Ala… Expand


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