Geneva Cocktail for Cytochrome P450 and P-Glycoprotein Activity Assessment Using Dried Blood Spots

@inproceedings{Bosilkovska2014GenevaCF,
  title={Geneva Cocktail for Cytochrome P450 and P-Glycoprotein Activity Assessment Using Dried Blood Spots},
  author={Marija Bosilkovska and Caroline Flora Samer and J D{\'e}glon and Manuele Rebsamen and Cristina Staub and Pierre Dayer and Bernard Walder and Jules Alexandre Desmeules and Youssef Daali},
  booktitle={Clinical pharmacology and therapeutics},
  year={2014}
}
The suitability of the capillary dried blood spot (DBS) sampling method was assessed for simultaneous phenotyping of cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) using a cocktail approach. Ten volunteers received an oral cocktail capsule containing low doses of the probes bupropion (CYP2B6), flurbiprofen (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), midazolam (CYP3A), and fexofenadine (P-gp) with coffee/Coke (CYP1A2) on four occasions. They received the cocktail alone… CONTINUE READING
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a practical approach to estimating pharmacokinetic parameters of caffeine in preterm infants

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