Genetics of variation in HDL cholesterol in humans and mice.

@article{Wang2005GeneticsOV,
  title={Genetics of variation in HDL cholesterol in humans and mice.},
  author={Xiaosong Wang and Beverly J. Paigen},
  journal={Circulation research},
  year={2005},
  volume={96 1},
  pages={27-42}
}
Plasma high-density lipoprotein cholesterol (HDL-C) concentrations are genetically determined to a great extent, and quantitative trait locus (QTL) analysis has been used to identify chromosomal regions containing genes regulating HDL-C levels. We discuss new genes found to participate in HDL metabolism. We also summarize 37 mouse and 30 human QTLs for plasma HDL-C levels, finding that all but three of the mouse QTLs have been confirmed by a second cross or a homologous human QTL, that the… CONTINUE READING

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