Genetics of type 2 diabetes: pathophysiologic and clinical relevance

@article{Herder2011GeneticsOT,
  title={Genetics of type 2 diabetes: pathophysiologic and clinical relevance},
  author={Christian Herder and Michael Roden},
  journal={European Journal of Clinical Investigation},
  year={2011},
  volume={41}
}
  • C. Herder, M. Roden
  • Published 1 June 2011
  • Medicine
  • European Journal of Clinical Investigation
Eur J Clin Invest 2011; 41 (6): 679–692 
View on Wiley
ncbi.nlm.nih.gov
173 Citations
Highly Influential Citations
6
Background Citations
79
Methods Citations
3
Results Citations
2

173 Citations

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Type 2 diabetes mellitus (T2DM) is associated with a progressive deterioration in beta cell function and loss of glycaemic control. Clinical predictors of beta cell failure are needed to guide…
Newly diagnosed diabetes - treatment plan and goals
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This video explains how the pancreas of people with diabetes change the whole dynamic of their lives as a result of the disease.
Allgemeine Grundlagen des Diabetes mellitus
Nach Schatzungen der International Diabetes Federation hatten im Jahr 2011 366 Mio. Personen im Alter zwischen 20 und 79 Jahren weltweit einen Diabetes mellitus.
A Longitudinal Study of Diabetes Mellitus : With Special Reference to Incidence and Prevalence, and to Determinants of Macrovascular Complications and Mortality
Objectives. To investigate diabetes prevalence, incidence, mortality trends, the effects of hyperglycaemia and blood pressure, diabetes and hypertension treatment, and the effect of screening detec…
Personalized medicine in Type 2 Diabetes
TLDR
Effect of genetic profiling on T2D and its complications, pharmacogenetics and pharmacogenomics of oral anitdiabetic drug will be explored and genetic association studies have shown polymorphisms at specific loci may help identify individuals at greatest risk and response to oral antidiabetic drugs.
Type 2 diabetes across generations: from pathophysiology to prevention and management
Interacción genoma-ambiente en la diabetes mellitus tipo 2
TLDR
Type 2 diabetes mellitus is more likely to appear when genetic and environmental factors coincide because it is a multifactorial disease in which the presence of genetic factors is not enough, but the action of a predisposing environment is required to appear.
Role of vitamin D receptor (VDR) genetic polymorphism in onset of type 2 diabetes mellitus: A Review
TLDR
The present review will focus on concept that polymorphism of VDR gene may has role in susceptibilty of onset of T2DM and its pathogenesises.
Sfrp5 associates with beta‐cell function in humans
TLDR
The aim of the study was to characterize the associations between serum Sfrp5 and indices of insulin sensitivity and beta‐cell function from dynamic measurements using oral glucose tolerance tests (OGTT) in humans.
Microbial Regulation of Glucose Metabolism and Insulin Resistance
TLDR
This review aims to generate a deeper understanding of the underlying mechanism of potential microbial strains, which can be used as probiotics in type 2 diabetes patients, to elucidate the complex interaction of gut microbiota, intestinal permeability and inflammation.
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References

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The genetic and evolutionary consequences of geographical differences in food history may provide the answer to why the prevalence of type 2 diabetes mellitus now exploding in most populations, but not in Europeans.
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TLDR
The extent to which human molecular genetic research has illuminated the understanding of their underlying pathophysiological mechanisms is explored, and type 2 diabetes and obesity are explored.
Genetic susceptibility to type 2 diabetes and implications for antidiabetic therapy.
TLDR
An improved understanding of genetic mechanisms should allow us to test whether behavioral or pharmacologic therapies can be tailored and thus the tremendous disease burden inflicted by type 2 diabetes alleviated.
Common variants in WFS1 confer risk of type 2 diabetes
TLDR
Using a gene-centric approach, it is shown that variation in WFS1 also predisposes to common type 2 diabetes.
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
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Insulin resistance and lipotoxicity represent the missing links (beyond the classical cardiovascular risk factors) that help explain the accelerated rate of CVD in type 2 diabetic patients.
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  • Medicine, Biology
    The New England journal of medicine
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TLDR
The design of genomewide association studies is described and the extent to which the data they provide are useful in predicting the risk of disease is considered.
Variation in FTO contributes to childhood obesity and severe adult obesity
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It is concluded that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
Learning From Molecular Genetics Novel Insights Arising From the Definition of Genes for Monogenic and Type 2 Diabetes
TLDR
New insights that have arisen from defining the etiological genes in monogenic diabetes and the predisposing polymorphisms in type 2 diabetes are examined.
Genomics of type 2 diabetes mellitus: implications for the clinician
TLDR
The current list of genetic loci that are related to T2DM does not seem to offer greater predictive value in determining diabetes risk than do commonly used phenotypic risk factors and family history.
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TLDR
The risk-conferring genotypes in TCF7L2 are associated with impaired beta-cell function but not with insulin resistance, and seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance.
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