Genetics of type 1 diabetes.

  title={Genetics of type 1 diabetes.},
  author={M. Ann Kelly and Catherine H Mijovic and Anthony Barnett},
  journal={Best practice & research. Clinical endocrinology & metabolism},
  volume={15 3},
Type 1 diabetes mellitus is a T-cell-mediated autoimmune disease characterized by the selective destruction of pancreatic beta cells. Susceptibility to the disease is determined by a combination of genetic and environmental factors. The genetic factors are termed 'susceptibility genes' as they modify the risk of diabetes but are neither necessary nor sufficient for disease to develop. A large number of chromosomal regions have been identified as containing potential diabetes susceptibility… CONTINUE READING
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