Genetics of type 1 diabetes mellitus

  title={Genetics of type 1 diabetes mellitus},
  author={Flemming Pociot and Michael F McDermott},
  journal={Genes and Immunity},
At least 20 different chromosomal regions have been linked to type 1 diabetes (T1D) susceptibility in humans, using genome screening, candidate gene testing, and studies of human homologues of mouse susceptibility genes. The largest contribution from a single locus (IDDM1) comes from several genes located in the MHC complex on chromosome 6p21.3, accounting for at least 40% of the familial aggregation of this disease. Approximately 30% of T1D patients are heterozygous for HLA-DQA1*0501–DQB1*0201… CONTINUE READING


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