Genetics of susceptibility and severity in systemic lupus erythematosus.

  title={Genetics of susceptibility and severity in systemic lupus erythematosus.},
  author={Jennifer A Croker and Robert Kimberly},
  journal={Current opinion in rheumatology},
  volume={17 5},
PURPOSE OF REVIEW The genetic basis of systemic lupus erythematosus, a complex genetic trait, may provide important insights into autoimmune disease. Innovation in both practical and theoretical approaches will assist in accelerating the pace of discovery and our understanding of pathogenesis. RECENT FINDINGS Significant progress has been made in the last year with respect to the refinement of genetic intervals to promising candidate genes involved in systemic lupus erythematosus pathogenesis… CONTINUE READING