Genetics of rheumatoid arthritis.

  title={Genetics of rheumatoid arthritis.},
  author={Carl Turesson and Eric L Matteson},
  journal={Mayo Clinic proceedings},
  volume={81 1},
Rheumatoid arthritis (RA) is a heterogeneous autoimmune disorder of unknown cause with variable clinical expression. About 70% of patients are women. Genetic factors play an important role and likely account for about 60% of disease susceptibility and expression. The association with the HLA-DRB1 gene is the best understood, although several non-HLA loci have been linked to RA, including the 18q21 region of the TNFRSR11A gene, which encodes the receptor activator of nuclear factor kappaB… CONTINUE READING